The Lab Notebook
Posts about
Tetramer
Correlation Between HLA Typing and Immune Monitoring in Human Disease
The HLA (human leukocyte antigen) system, also known as the human MHC (major histocompatibility...
Human MHC Class II QuickSwitch™ Platform is used to Identify SARS-CoV-2 Virus Derived Peptides
In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have...
How to Identify SARS-CoV-2 Virus Derived Peptides
In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have...
Find Human MHC Class I Dominant Peptides
In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have...
Comparing Theoretical Peptide-MHC Binding Affinity to Real Values produced by the QuickSwitch™ Platform
In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have
How to screen SARS-CoV-2 peptides to facilitate T cell research
Whenever our immune system is faced with a challenge, be it a multicellular parasite, a bacteria, a...
MuLV gp70 (AH1) Tetramer - a great tool for observing antigen specific immune response in cancer
MuLV gp 70, also designated as AH1 (SPSYVYHQF), is an endogenous viral envelope glycoprotein...
In vivo NIRF whole-body imaging through MHC tetramers
The use of MHC tetramers for the detection of antigen specific T cells has been a well-established...
Screening for COVID-19 T-cell peptides and immune monitoring with MHC tetramers in a single assay
COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed...
Cancer Immunotherapy - Growing focus on CD4+ T lymphocytes and MHC Class II Neoantigens
It is now well accepted that CD8+ T cells play a central role in mediating anti-tumor immunity by...
Is your drug candidate able to reverse the T Cell Exhaustion-like state in our in vitro functional screening assay?
The goal of cancer immune checkpoint therapies is to cure tumor-specific T cells from dysfunction...
New tetramer for vaccine research targeting Tuberculosis and Ag85B specific T-cells
Tuberculosis (TB) is caused by the Mycobacterium tuberculosis and usually targets the lungs. This...
QuickSwitch, a tool for adoptive T cell transfer
Our understanding of how the immune system responds to cancer has increased by leaps and bounds in...
Gating strategy for tetramer analysis to eliminate non-specific event
While MHC tetramer staining of antigen specific T cells for flow cytometry is considered highly...
Which tetramers can be used for my mouse samples?
The thymus shapes a host's T-cell repertoire so they do not respond to "self" antigens, yet are...
Quick! Switch out your peptide!
The immunotherapy field is making great progress in aiding many disease treatments. The hope is...
Quick! Switch out your peptide!
The immunotherapy field is making great progress in aiding many disease treatments. The hope is...
Don't be fooled. Not all tetramers are created equal!
Have you seen comparisons of multimer technology claiming to be superior to tetramers? Be sure to...
Help! My mouse tetramer stained ALL the CD8+ T cells!
You’re sitting at your flow cytometer, staring at your CD8 x tetramer plot in anticipation of a...
Be positive! 5 ways to confirm your MHC tetramer is binding
In the previous Tetramer Tips blog, I suggested ways for you to be a negative Control Freak. Now...
Tetramer Tips for Success: How to be a (Negative) Control Freak
While being a Control Freak may not be the best choice for living in spiritual harmony, it is a...