--- title: Quick!  Switch out your peptide!  description: Have greater control by creating your own tetramers with MBLI's QuickSwitch kit! image: https://blog.mblintl.com/hubfs/Tetramer/Marc_Replace%204.JPG.png --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - Quick!  Switch out your peptide!  # Quick!  Switch out your peptide!  ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Marc Delcommenne, PhD](https://blog.mblintl.com/author/marc-delcommenne-phd) on Mar 27, 2018 12:58:00 PM ![](https://blog.mblintl.com/hubfs/Tetramer/Marc_Replace%204.JPG.png) The immunotherapy field is making great progress in aiding many disease treatments.  The hope is that one day, personalized immunotherapy can be used so each patient can use their own immune system to overcome their specific disease affliction.  QuickSwitch is a tool for creating custom MHC class I tetramers quickly and easily. There is currently a great interest in discovering novel peptide sequences from pathogens or tumors (neo-epitopes) that can be used for developing various CD8+ T cell based immunotherapies. The combination of whole-exome and transcriptome sequencing analysis with mass spectrometry now permits rapid identification of a myriad of peptide candidates. As a first screening step, potential binders to MHC molecules can be determined using MHC class I prediction algorithms. However, these algorithms typically generate a large proportion of false binders, therefore requiring experimental validation. To make this task easier, we have devised a fast, affordable and　*user*-*friendly* assay ([QuickSwitch Quant kit](https://products.mblintl.com/?s=tb-7300&post_type=product&title=1&excerpt=1&content=1&categories=1&attributes=1&tags=1&sku=1&orderby=rating-DESC&ixwps=1)) that can both help determine binding of peptides to MHC class I molecules and generate MHC class I tetramers with these peptides for detection of peptide specific T cells.　 Peptide exchange does not require any special instrument.　 Peptides are added to tetramers along with a peptide exchange factor.　 After a 4 hour incubation, peptide exchange is assessed by a capture assay and quantitated by flow cytometry.　 New peptide specificity tetramers can then be used directly for staining T cells.　  ![Schematic of QuickSwitch Assay](https://blog.mblintl.com/hs-fs/hubfs/Tetramer/QuickSwitchNov1.jpg?width=591&name=QuickSwitchNov1.jpg "Schematic of QuickSwitch Assay")   ![Time line for QuickSwitch peptide exchange](https://blog.mblintl.com/hs-fs/hubfs/Tetramer/QuickSwitchNov2.jpg?width=1584&name=QuickSwitchNov2.jpg "Time line for QuickSwitch peptide exchange") Here is a diagram showing how QuickSwitch Quant assay for peptide exchange works: ![How peptide exchange works using QuickSwitch](https://blog.mblintl.com/hs-fs/hubfs/Tetramer/Marc_Replace%204.JPG.png?width=618&name=Marc_Replace%204.JPG.png "How peptide exchange works using QuickSwitch") Kits are available with one human allele (HLA-A\*02:01) and one mouse allele (H-2 Kb).　 More alleles will follow in the near future.　 Quickswitch tetramers are available with three fluorochromes: Phycoerythrin (PE), Allophycocyanin (APC), or Brilliant Violet 421 (BV421).　 Finally, we also provide [Quickswitch kits without the peptide exchange quantitation module](https://products.mblintl.com/?s=tb-7300&post_type=product&title=1&excerpt=1&content=1&categories=1&attributes=1&tags=1&sku=1&orderby=rating-DESC&ixwps=1).　 This version may interest researchers who are absolutely sure their peptides are good binders- based on literature, from existing commercial multimers or previous experiments.  This provides a significant cost benefit (several tetramers can be made for the price of one) and frees up time (don't have to wait for custom-made tetramers).  Both the Quant kit and Non-Quant kits allow for sensitive peptide sequences to remain confidential.  ![QuickSwitch tetramers are great for detecting low and high affinity CMV responses!](https://blog.mblintl.com/hs-fs/hubfs/Tetramer/QuickSwitchgraphs.jpg?width=591&name=QuickSwitchgraphs.jpg "QuickSwitch tetramers are great for detecting low and high affinity CMV responses!") MBLI offers QuickSwitch kits as well as stock and custom peptides.  Click [here](https://www.mblintl.com/products/stock-custom-peptides/) to learn more about our peptide offerings. [![Get your free Tetramer Staining Guide here!](https://no-cache.hubspot.com/cta/default/424171/cfa9eb0d-e985-4f35-a47b-5be6c7d5ce9b.png)](https://cta-redirect.hubspot.com/cta/redirect/424171/cfa9eb0d-e985-4f35-a47b-5be6c7d5ce9b)   Tags: [Tetramer](https://blog.mblintl.com/topic/tetramer), [QuickSwitch](https://blog.mblintl.com/topic/quickswitch), [Peptide](https://blog.mblintl.com/topic/peptide), [Peptide Exchange](https://blog.mblintl.com/topic/peptide-exchange) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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