Mitophagy is the selective degradation of old or depolarized mitochondria by autophagy, mitophogy contributes to maintaining a healthy population of mitochondria. Since damaged mitochondria leads to collapsed cell homeostasis, mitophagy is believed to protect against diseases related to mitochondrial dysfunction such as neurodegenerative disorders, most importantly Parkinson's Disease.
Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.
Antibodies are wonderful. They can act as little detectives to help you determine if the protein you’re interested in is involved in a certain process or help characterize the function. But what if your favorite protein has two forms? Is your antibody sophisticated enough to be able to detect one form over the other? Does this knowledge help you? How? IL-18 is one such protein that has two forms. It is present when it is inactive and present when it is active. So what is known about IL-18 and its function and the two forms it can exist in?