--- title: IL-18 Biomarker and Potential Therapeutic Target description: This article highlights some of the many therapies that target IL-18 activation and inhibition in different inflammatory diseases. image: https://blog.mblintl.com/hs-fs/hubfs/1Cytokine%20Storms%20Immune%20Reactions%20in%20Autoimmunity-1.png?width=499&quality=high --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - IL-18 Biomarker and Potential Therapeutic Target # IL-18 Biomarker and Potential Therapeutic Target ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Beata Boczkowska, Ph.D.](https://blog.mblintl.com/author/beata-boczkowska-ph-d) on Jul 23, 2024 4:04:09 PM ![](https://blog.mblintl.com/hs-fs/hubfs/1Cytokine%20Storms%20Immune%20Reactions%20in%20Autoimmunity-1.png?width=499&quality=high) IL-18 is a potent pro-inflammatory cytokine that plays a vital role in the body's defense against infections and regulates both the innate and acquired immune response. Understanding the balance between IL-18 and its binding protein, IL-18BP, is crucial as their dysregulation can lead to adverse outcomes. Naturally IL-18 exists in two forms- pro IL-18 and the mature IL-18. It is first present in the pro-form precursor and lacks the signal sequence required for secretion. ICE (IL-1β Converting Enzyme) or Caspase 1 cleaves Pro-IL-18 activating IL-18. This active form is seen in body tissues and carries out IL-18 function which is essential in immune defenses. Whereas the IL-18 binding protein is a naturally secreted molecule that binds to and neutralizes IL-18, inhibiting the interaction between IL-18 and IL-18R, thereby reducing IFN γ induction. Hence, the dysregulation of the IL-18/IL-18BP balance has various biological effects and can lead to pathological outcomes. Both IL-18 and IL18BP have been associated with the development of psoriasis, atopic dermatitis (AD), lupus erythematosus (LE), and other inflammatory skin diseases. For certain types of cancers, such as pancreatic cancer and multiple myeloma, IL-18 has the potential to have pro-tumoral activity. While IL-18 can enhance host immune responses, caution should be exercised when considering IL-18 therapy due to its potential to also promote cancer aggressiveness. ![il18](https://blog.mblintl.com/hs-fs/hubfs/il18.jpg?quality=high&width=586&height=466&name=il18.jpg)Given the biological properties of IL-18 and its significant role in various diseases, it is no wonder that extensive attention is being directed towards IL-18 in drug discovery and therapy research. Overall, the therapeutic effects of IL-18 therapy involve stimulating monocytes, NK cells, and T cells, leading to the production of IFN-γ and other cytokines within the body. IL-18 seems to primarily function as a costimulatory cytokine, suggesting that its optimal utilization in cancer immunotherapy could involve combining it with other immunostimulatory cytokines, vaccines, or monoclonal antibodies. Currently, drug therapy is more focused on IL-18 inhibitors or agonists in addition to other cytokines. The inhibitors and IL-18BP drugs in clinical trials and preclinical studies for the treatment of inflammatory diseases. 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