The Lab Notebook

Why pure exosome isolation matters

Posted by Lise Peeters, PhD on Mar 28, 2017 11:30:00 AM

Exosomes are cell-derived vesicles originating from multi-vesicular bodies and found in biological fluids such as blood, saliva, urine, and breast milk. Sizes of these extracellular vesicles (EVs) range between 30-100 nm. Due to their capacity to transfer proteins, lipids and nucleic acids, exosomes can influence various physiological and pathological functions (Yañez-Mo et al., 2015).

Exosomes play a key role in cell-cell communication and circulate in bloodstream, and therefore, are implicated as a disease biomarker for cancer and immune system disorders. However, there is limited information regarding efficient methods for obtaining pure exosomes. MBL offers a unique exosome purification kit that can help researchers purify exosomes from their sample.

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Tags: Cancer, Exosomes, Liquid Biopsy, Exosome, Biomarker, Purify exosome

Give Your Research 100% With a S100 Antibody

Posted by Deane Buckley on Jul 7, 2015 10:00:00 AM

 

Figure: Schematic representation of S100 proteins in the MAP kinase and NF-kappaB pathways.

S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.

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Tags: Immunology, Apoptosis, Cancer

The Fas and the Furious 2: The Importance of Fas in Cancer

Posted by Deane Buckley on May 13, 2015 3:14:46 PM

 

Given the prominent role of Fas in many important cell functions (7 Facts to Catch You Up to Speed on Fas), Fas has been implicated in a variety of disease states such as cancer. Here are some major findings from recent research about the role of Fas in cancer:

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Tags: Apoptosis, Cancer

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