--- title: "The Fas and the Furious 2: The Importance of Fas in Cancer" description: The role of the Fas protein in cancer is discussed. image: https://blog.mblintl.com/hubfs/Deane_Blog/The_Fas_and_the_Furious_2.jpg --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - The Fas and the Furious 2: The Importance of Fas in Cancer # The Fas and the Furious 2: The Importance of Fas in Cancer ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Deane Buckley](https://blog.mblintl.com/author/deane-buckley) on May 13, 2015 3:14:46 PM ![](https://blog.mblintl.com/hubfs/Deane_Blog/The_Fas_and_the_Furious_2.jpg)   Given the prominent role of Fas in many important cell functions ([7 Facts to Catch You Up to Speed on Fas](https://blog.mblintl.com/the-fas-and-the-furious-7-facts-to-catch-you-up-to-speed-on-fas)), Fas has been implicated in a variety of disease states such as cancer. Here are some major findings from recent research about the role of Fas in cancer: **Role of Fas in Cancer** Mutations in the genes that encode for Fas have been found to increase the risk of developing many types of cancer such as breast, gastric and esophageal1. However, high levels of Fas expression in cancer cells have been found to be a positive prognostic marker for cancer patients, indicating higher survival rates2. It has been found that immune cells called CD8+ cytotoxic lymphocytes can kill cancer cells by binding to Fas with Fas ligand3. **Resistance Mechanisms** However, cancer cells have developed many resistance mechanisms to these immune cells: 1. Cancer cells can lower the expression of Fas on the cell surface. Cancer cells can alter the levels of Fas transporters FAP-1 and dynamin which lowers the level of Fas transport to the cell surface. Lower levels of Fas on the cancer cell surface decrease the ability of CD8+ cytotoxic lymphocytes to bind and kill cancer cells4. 2. Many cancer cells can develop resistance by increasing the expression of a protein on its cell surface called cFLIP. cFLIP interferes with apoptosis by blocking the Fas receptor from activating caspases. Without caspase activation, Fas cannot induce apoptosis3. 3. Recent research has suggested that cancer cells can “counterattack” and induce apoptosis in T cells by expressing Fas ligand. However, the existence of this method of resistance is debated3. **Therapeutic Targeting of Fas** Given their prominent role in cancer, drugs targeting Fas has been explored as a potential treatment for cancer5. One possible type of treatment is an antibody targeting Fas. However, major side effects of using a Fas antibody to target Fas have been found to be lethal in mice. This lethality was caused by the Fas antibody targeting healthy cells in the liver causing severe damage5. Other treatments that do not directly target Fas are being explored such as IAP antagonists. IAP inhibits effector caspases which are necessary for Fas-induced apoptosis to occur5. Given the importance of Fas in cancer, research in Fas is a very hot topic. MBL International offers a variety of products to help further your research of Fas including many Anti-Fas antibodies: - [Anti-Fas (CD95) monoclonal antibody](https://products.mblintl.com/products/sy-001)             Applications: WB, FCM - [Anti-Fas (CD95) (Human) mAb-FITC](https://products.mblintl.com/products/md-10-4)               Applications: IHC, FCM - [Anti-Fas Ligand (CD178) (Human) mAb-FITC](https://products.mblintl.com/products/d041-4)  Applications: ELISA, FCM    ![The_Fas_and_the_Furious_2](https://blog.mblintl.com/hubfs/Deane_Blog/The_Fas_and_the_Furious_2.jpg) [![Apoptosis Pathway Poster](https://no-cache.hubspot.com/cta/default/424171/bacc800b-cb87-47b2-97e9-a13271642ee5.png)](https://cta-redirect.hubspot.com/cta/redirect/424171/bacc800b-cb87-47b2-97e9-a13271642ee5)   1. [Xu Y, He B, Li R, et al. Association of the polymorphisms in the Fas/FasL promoter regions with cancer susceptibility: a systematic review and meta-analysis of 52 studies. PLoS ONE. 2014;9(3):e90090.](http://www.ncbi.nlm.nih.gov/pubmed/24598538) 2. [Chan KW, Lee PY, Lam AK, Law S, Wong J, Srivastava G. Clinical relevance of Fas expression in oesophageal squamous cell carcinoma. J Clin Pathol. 2006;59(1):101-4.](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860271/) 3. [Peter ME, Hadji A, Murmann AE, et al. The role of CD95 and CD95 ligand in cancer. Cell Death Differ. 2015;22(4):549-59.](http://www.ncbi.nlm.nih.gov/pubmed/25656654) 4. [Ivanov VN, Ronai Z, Hei TK. Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. J Biol Chem. 2006;281(3):1840-52.](http://www.ncbi.nlm.nih.gov/pubmed/16306044) 5. [Kaufmann T, Strasser A, Jost PJ. Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ. 2012;19(1):42-50.](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252833/)       Tags: [Apoptosis](https://blog.mblintl.com/topic/apoptosis), [Cancer](https://blog.mblintl.com/topic/cancer) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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