Give Your Research 100% With a S100 Antibody

Figure: Schematic representation of S100 proteins in the MAP kinase and NF-kappaB pathways.

S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.

1. The S100 protein family consists of 21 proteins that exhibit structural similarity. However, many of the proteins differ in their function¹.
2. Calcium binding activates S100 proteins. S100 proteins undergo a conformation change, thereby allowing interaction with other proteins².
3. S100 proteins regulate levels of nucleic acids and a variety of proteins such as enzymes, receptors and transcription factors³.
4. Some S100 proteins interact with intracellular targets. An example is S100A6, which can bind p53 in the cytosol to regulate apoptosis³.
5. Some S100 proteins interact with extracellular targets. These interactions include binding to extracellular receptors or binding extracellular circulating proteins³.
6. S100 proteins are involved in many important cellular processes such as apoptosis, inflammation, energy metabolism and proliferation³.
7. S100 proteins have been implicated in a variety of cancers^1,2. The specific ways S100 proteins are involved in cancer will be discussed in a future post.

MBL International offers a variety of S100 products to meet your research needs including S100 antibodies and S100 ELISA Kits. With a S100 antibody and a S100 ELISA kit, it'll be easier for you to further explore these fascinating proteins.

• Anti-S100A6 Polyclonal Antibody Application: WB
• S100A12/EN-RAGE ELISA Kit
• CircuLex S100A9/MRP14 ELISA Kit
• CircuLex S100A8/MRP8 ELISA Kit

Citations:

1. Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer. Nat Rev Cancer. 2015;15(2):96-109.

2. Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4(2):89-115.

3. Donato R, Cannon BR, Sorci G, et al. Functions of S100 proteins. Curr Mol Med. 2013;13(1):24-57.