Published by Deane Buckley on
Figure: Schematic representation of S100 proteins in the MAP kinase and NF-kappaB pathways.
S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.
- The S100 protein family consists of 21 proteins that exhibit structural similarity. However, many of the proteins differ in their function1.
- Calcium binding activates S100 proteins. S100 proteins undergo a conformation change, thereby allowing interaction with other proteins2.
- S100 proteins regulate levels of nucleic acids and a variety of proteins such as enzymes, receptors and transcription factors3.
- Some S100 proteins interact with intracellular targets. An example is S100A6, which can bind p53 in the cytosol to regulate apoptosis3.
- Some S100 proteins interact with extracellular targets. These interactions include binding to extracellular receptors or binding extracellular circulating proteins3.
- S100 proteins are involved in many important cellular processes such as apoptosis, inflammation, energy metabolism and proliferation3.
- S100 proteins have been implicated in a variety of cancers1,2. The specific ways S100 proteins are involved in cancer will be discussed in a future post.
MBL International offers a variety of S100 products to meet your research needs including S100 antibodies and S100 ELISA Kits. With a S100 antibody and a S100 ELISA kit, it'll be easier for you to further explore these fascinating proteins.
- Anti-S100A6 Polyclonal Antibody Application: WB
- S100A12/EN-RAGE ELISA Kit
- CircuLex S100A9/MRP14 ELISA Kit
- CircuLex S100A8/MRP8 ELISA Kit
Citations:
1. Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer. Nat Rev Cancer. 2015;15(2):96-109.
2. Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4(2):89-115.
3. Donato R, Cannon BR, Sorci G, et al. Functions of S100 proteins. Curr Mol Med. 2013;13(1):24-57.