The Lab Notebook

Deane Buckley

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Recent Posts

Stop Crying in the Lab: How Cry Antibodies Can Help Your Research

Posted by Deane Buckley on Jul 27, 2015 10:00:00 AM

 

Figure: Schematic representation of feedback loop involving CLOCK-BMAL1 complex and CRY and PER proteins involved in creating circadian rhythms.

Tiredness and frustration often mount after long nights in the lab. Why can’t our bodies adjust and allow us to maintain our energy through the night? The answer lies in our circadian rhythms. Circadian rhythms are the daily cycle of biological processes such as wakefulness and metabolism1. Many proteins are involved in regulating our circadian rhythms including CRY proteins. This blog post will catch you up on these proteins and their vital role in regulating circadian rhythms.

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Give Your Research 100% With a S100 Antibody

Posted by Deane Buckley on Jul 7, 2015 10:00:00 AM

 

Figure: Schematic representation of S100 proteins in the MAP kinase and NF-kappaB pathways.

S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.

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Topics: Immunology, Apoptosis, Cancer

Elevate Your Research: New Pathways of Study For Your PCSK9 ELISA Kit

Posted by Deane Buckley on Jun 22, 2015 9:00:00 AM

Figure: Schematic representation of PCSK-cIAP1 Binding Assay Kit which can be used to screen inhibitors of PCSK9-cIAP1 interaction during apoptosis.

 

As discussed in two prior blog posts, PCSK9 has primarily been studied for its role in regulating cholesterol levels and as a target for treatments to lower cholesterol. However, PCSK9 has been found to be involved in many other important pathways.

This blog post will catch you up on the latest research into the diverse functions of PCSK9.

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Topics: Apoptosis

Elevate your Cholesterol Research Part 2: How Our PCSK9 ELISA Kit Can Help You

Posted by Deane Buckley on Jun 8, 2015 11:00:00 AM

Schematic of PCSK9 Binding Kit

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Topics: Metabolism

Elevate Your Cholesterol Research: How a PCSK9 ELISA Kit Can Help You

Posted by Deane Buckley on Jun 2, 2015 10:58:00 AM

Graphic of PCSK9 Pathway. Useful for study of PCSK9 using PCSK9 ELISA Kits and Antibodies 

Ever wonder how cholesterol levels are regulated? One of the major regulators is a molecule called proprotein convertase subtilisin/kexin type 9 or PCSK9 for short! PCSK9 has been implicated in causing hypercholesterolemia (high cholesterol), and diseases such as coronary heart disease1.

This blog post will get you caught up on cholesterol and research on PCSK9's role in cholesterol regulation.

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Topics: Metabolism

The Fas and the Furious 2: The Importance of Fas in Cancer

Posted by Deane Buckley on May 13, 2015 3:14:46 PM

 

Given the prominent role of Fas in many important cell functions (7 Facts to Catch You Up to Speed on Fas), Fas has been implicated in a variety of disease states such as cancer. Here are some major findings from recent research about the role of Fas in cancer:

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Topics: Apoptosis, Cancer

The Fas and the Furious: 7 Facts to Catch You Up to Speed on Fas and How a Fas Antibody Can Help Your Research

Posted by Deane Buckley on Apr 30, 2015 11:09:00 AM

 

Apoptosis induced by Fas antibody

Fas antigen is a receptor protein that has been linked to many diseases such as cancer1 and autoimmune diseases2. Here are seven findings from research on this protein to catch you up to speed on Fas:

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Topics: Apoptosis

The Significance of IL-18 in the Inflammatory Response

Posted by Deane Buckley on Mar 9, 2015 10:30:48 AM

Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.

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Topics: Immunology, IL-18, Immune Response, Allergy