--- title: "Elevate Your Cholesterol Research: How a PCSK9 ELISA Kit Can Help You" description: PCSK9 regulates LDL cholesterol and how to measure with PCSK9 ELISA Kits --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - Elevate Your Cholesterol Research: How a PCSK9 ELISA Kit Can Help You # Elevate Your Cholesterol Research: How a PCSK9 ELISA Kit Can Help You ### Topics \- Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Deane Buckley](https://blog.mblintl.com/author/deane-buckley) on Jun 2, 2015, 10:58:00 AM ![PCSK9-1](https://blog.mblintl.com/hs-fs/hubfs/PCSK9-1.png?width=600&name=PCSK9-1.png)  **Ever wonder how cholesterol levels are regulated?** One of the major regulators is a molecule called proprotein convertase subtilisin/kexin type 9 or PCSK9 for short! PCSK9 has been implicated in causing hypercholesterolemia (high cholesterol), and diseases such as coronary heart disease1. This blog post will get you caught up on cholesterol and research on PCSK9's role in cholesterol regulation. 1. Cholesterol is an essential fat for proper cell functioning. Cholesterol is transported through the body by two types of proteins: Low density lipoproteins (LDL) and high density lipoproteins (HDL)2. 2. LDL cholesterol stays in the bloodstream unless it is absorbed. LDL cholesterol needs to bind to LDL receptors in order to be removed from the bloodstream1. 3. Once LDL cholesterol binds to its receptor, it is internalized into the bloodstream by endocytosis. Endocytosis is a process by which proteins and other molecules are transported into a cell by being engulfed into a fluid-filled sac called a vesicle1. 4. PCSK9 is a protease which is a type of protein that helps catalyze the degradation of other proteins3. 5. PCSK9 binds to LDL receptors and directs them to cellular lysosomes which can degrade LDL receptors ([See above graphic of PCSK9 pathway](https://blog.mblintl.com/hubfs/PCSK9_Pathway_Graphic.gif)). Therefore, decreased levels of PCSK9 can lower levels of LDL cholesterol in the bloodstream3. 6. High levels of LDL cholesterol in the bloodstream can lead to many diseases such as coronary heart disease1. It is thought that inhibiting PCSK9 can lower cholesterol levels which would help treat and lower the risk of getting these diseases3. 7. Many drugs are being developed that target PCSK9 to lower cholesterol. These include antibodies and siRNA3 which will be discussed in a future blog post. (Stay Tuned) 8. PCSK9 levels are regulated by a protein called SREBP2 which binds to DNA and increases the amount of PCSK9 produced1. 9. PCSK9 is also thought to play a role in lipid metabolism4 and susceptibility to hepatitis C infection in the liver5. **PCSK9 ELISA Kits and Antibodies** Measuring levels of PCSK9 is important for researchers who are trying to regulate cholesterol. - [Human PCSK9 ELISA Kit](https://products.mblintl.com/products/cy-8079) - [PCSK9-LDLR *in vitro* Binding Assay Kit](https://products.mblintl.com/products/cy-8150) - [Mouse/Rat PCSK9 ELISA Kit](https://products.mblintl.com/products/cy-8078) - [PCSK9 monoclonal antibody Application: IPP, WB](https://products.mblintl.com/products/cy-m1033)     1\. [Farnier M. PCSK9: From discovery to therapeutic applications. Arch Cardiovasc Dis. 2014;107(1):58-66.](http://www.ncbi.nlm.nih.gov/pubmed/24373748) 2\. [Nlm.nih.gov. Cholesterol Levels: What You Need to Know | NIH MedlinePlus the Magazine. 2015.](http://www.nlm.nih.gov/medlineplus/magazine/issues/summer12/articles/summer12pg6-7.html)  3\. [Ahn CH, Choi SH. New drugs for treating dyslipidemia: beyond statins. Diabetes Metab J. 2015;39(2):87-94.](http://www.ncbi.nlm.nih.gov/pubmed/25922802) 4\. [Levy E, Ben djoudi ouadda A, Spahis S, et al. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis. 2013;227(2):297-306.](http://www.ncbi.nlm.nih.gov/pubmed/?term=PCSK9+plays+a+significant+role+in+cholesterol+homeostasis+and+lipid+transport+in+intestinal+epithelial+cells) 5\. [Seidah NG, Sadr MS, Chrétien M, Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J Biol Chem. 2013;288(30):21473-81.](http://www.ncbi.nlm.nih.gov/pubmed/?term=The+multifaceted+proprotein+convertases%3A+their+unique%2C+redundant%2C+complementary%2C+and+opposite+functions)     Tags: [Metabolism](https://blog.mblintl.com/topic/metabolism) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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