Fas antigen is a receptor protein that has been linked to many diseases such as cancer1 and autoimmune diseases2. Here are seven findings from research on this protein to catch you up to speed on Fas:
In conclusion, Fas has been implicated in a variety of different roles for proper cell function. Its major importance in many disease states will be discussed in a future blog post.
To further learn about Fas, MBL International offers many products such as fas antibody to further your research:
1. Zhong-xing Z, Yuan-yuan M, Hai zhen M, Jian-gang Z, Li-feng Z. FAS-1377 G/A (rs2234767) polymorphism and cancer susceptibility: a meta-analysis of 17,858 cases and 24,311 controls. PLoS ONE. 2013;8(8):e73700.
2. Kaufmann T, Strasser A, Jost PJ. Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ. 2012;19(1):42-50.
3. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495-516.
4. Jost PJ, Grabow S, Gray D, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009;460(7258):1035-9.
5. Strasser A, Jost PJ, Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity. 2009;30(2):180-92.
6. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9(1):47-59.