The Lab Notebook

Learn why IL-18 is an exciting biomarker for various diseases

Posted by Tomohiro Nakajo on Jul 31, 2018 1:00:00 PM

As described in previous blog posts, our IL-18 related products are used widely among researchers around the world. IL-18 plays an important role in the cytokine network. Abnormal values of IL-18 are seen in various disease areas such as allergy or autoimmune diseases. 

In this blog, we discuss two diseases correlated with IL-18. Neither of them are allergy or autoimmune diseases, but very interesting nonetheless.

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Tags: IL-18, ELISA, pro IL-18

Improve your neutralization using monoclonal IL-18 antibodies

Posted by Tomohiro Nakajo on Jun 19, 2018 1:00:00 PM

Interleukin-18 (IL-18) is a member of the IL-1 superfamily and synthesized as an inactive precursor that requires processing by caspase-1 to become an active cytokine. IL-18 plays a major role in the production of interferon-γ (IFN-γ) from T cells and natural killer cells. Refresh your memory by reviewing a couple of previous blog posts.

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Tags: IL-18, ELISA, pro IL-18

Tips for successful results using our extremely popular IL-18 ELISA kits

Posted by Tomohiro Nakajo on May 30, 2018 1:00:00 PM

Interleukin-18 (IL-18) is a member of the IL-1 superfamily and synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine. IL-18 plays a major role in the production of interferon-γ (IFNγ) from T cells and natural killer cells. Refresh your memory by reviewing a couple of previous blog posts.

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Tags: IL-18, ELISA, pro IL-18

The Significance of IL-18 in the Inflammatory Response

Posted by Deane Buckley on Mar 9, 2015 10:30:48 AM

Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.

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Tags: Immunology, IL-18, Immune Response, Allergy

Why bother knowing if you are detecting Pro-IL18 or active IL-18?

Posted by Bindi M. Doshi, PhD on Mar 2, 2015 9:48:00 AM

il-18-01Antibodies are wonderful.  They can act as little detectives to help you determine if the protein you’re interested in is involved in a certain process or help characterize the function.  But what if your favorite protein has two forms?  Is your antibody sophisticated enough to be able to detect one form over the other?  Does this knowledge help you?  How?  IL-18 is one such protein that has two forms.  It is present when it is inactive and present when it is active.  So what is known about IL-18 and its function and the two forms it can exist in?

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Tags: Immunology, IL-18, Immune Response, Allergy

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