---
title: "Antibodies for fluorescent proteins: Will it cross react with my variant?"
description: Green fluorescent protein (GFP) was first isolated by Dr. Osamu Shimomura in 1961.
image: https://blog.mblintl.com/hubfs/FluorescentBlog.jpg
---

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- Antibodies for fluorescent proteins: Will it cross react with my variant?

# Antibodies for fluorescent proteins: Will it cross react with my variant?

### Topics

- Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine

### Top Posts

### Subscribe to our Blogs

Published by [Tomohiro Nakajo](https://blog.mblintl.com/author/tomohiro-nakajo) on Feb 27, 2018 1:00:00 PM

![](https://blog.mblintl.com/hubfs/FluorescentBlog.jpg)

Green fluorescent protein (GFP) was first isolated by Dr. Osamu Shimomura in 1961. Since then, fluorescent protein (FP) technology has made drastic advancements by many researchers. Currently, FP technology is the most popular tool for visualizing target proteins. Dr. Shimomura, Martin Chalfie and Roger Y. Tsien won the 2008 Nobel Prize in Chemistry to mark their great achievements in life science research.

![FluorescentBlog.jpg](https://blog.mblintl.com/hs-fs/hubfs/FluorescentBlog.jpg?width=369&name=FluorescentBlog.jpg)MBLI offers the *CoralHue*® FP series such as Keima-Red, Kusabira-Orange, and many others. We also offer antibodies agaist FPs.

FP antibodies are used for multiple purposes including pull-down assays, used as epitope-tag, increasing fluorescent intensity if the FP fluorescence is not bright enough, as well as other applications. MBLI offers polyclonal and monoclonal anti-GFP and anti-RFP antibodies with various conjugates including HRP, Agarose, and Magnetic beads.  In fact, many researchers prefer to use our bead conjugates for pull-down assays. Our GFP polyclonal antibody (598) is highly regarded to have high performance and reliability among many reseachers. There are over 500 citations to date using this FP antibody.

| **Code#** | **Description** | **Clone** | **Applications** | **Conjugates Available** | **Notes** |
| --- | --- | --- | --- | --- | --- |
| [598](https://products.mblintl.com/products/598) | Anti-GFP pAb | Polyclonal | WB, IP, IC, IH, ChIP\*, Immunoelectron Microscopy | HRP | Cumulative citations over 500 |
| [D153-3](https://products.mblintl.com/products/d153-3) | Anti-GFP mAb | RQ2 | IP, IC | Agaraose, Magnetic beads, Magnetic Agarose, Alexa-Fluor | Excellent performance in IP and staining |
| [PM005 ](https://products.mblintl.com/products/pm005) | Anti-RFP pAb | Polyclonal | WB, IC, IH\* | HRP | Highly cited |
| [M165-3](https://products.mblintl.com/products/m165-3)  | Anti-RFP mAb | 3G5 | IP, FCM, IC | Agarose, Magentic beads, Magentic Agarose | Specialized for IP |
| [M204-3 ](https://products.mblintl.com/products/m204-3) | Anti-RFP mAb | 1G9 | WB | HRP | Specialized for WB |
| [M208-3](https://products.mblintl.com/products/m208-3) | Anti-RFP mAb | Cocktail (1G9 and 3G5) | WB, IP, FCM, IC |   | For multiple applications |

 

There are many FP variants available today from different resources. Are there the same number of antibodies as FP variants? The answer is no, because FP antibodies have the possibility to cross react to various variants due to high homology among those variants. Our antibodies have been tested for cross reactivity to some variants as shown in the \*table below. An open circle shows we have tested our FP antibody with the corresponding variant.  N.T. indicates that we have not tested against the variant.

![Cross Reactivity GFP_resized.jpg](https://blog.mblintl.com/hs-fs/hubfs/Cross%20Reactivity%20GFP_resized.jpg?width=626&name=Cross%20Reactivity%20GFP_resized.jpg) \*Reported in articles![FluorescentBlog3.jpg](https://blog.mblintl.com/hs-fs/hubfs/FluorescentBlog3.jpg?width=1027&name=FluorescentBlog3.jpg)\*Reported in articles

Please don’t fret if you don’t see your variant listed!  If your FP is not seen in the table above, we can estimate cross reactivity by running a homology search between our antigen and your FP. The following link is a protein BLAST search between our GFP antigen (full length of GFP derived from *Aequorea victoria*) and your FP. If the homology is high enough, polyclonal antibody (598) has a good possibility that it will cross react with your FP because this antibody has multiple epitopes.

[![Run Blast](https://no-cache.hubspot.com/cta/default/424171/de5e04e8-72da-4e8e-8fd9-917dad70037a.png)](https://cta-redirect.hubspot.com/cta/redirect/424171/de5e04e8-72da-4e8e-8fd9-917dad70037a)

And of course- if you have any questions, please don't hesitate to [contact us](https://mblintl.com/about-mbli/contact-us/)!

Tags: [Fluorescent Proteins](https://blog.mblintl.com/topic/fluorescent-proteins), [Antibodies](https://blog.mblintl.com/topic/antibodies)

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