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Screening for COVID-19 T-cell peptides and immune monitoring with MHC tetramers in a single assay

Posted by Pirouz Daftarian, Ph.D., Marc Delcommenne, Ph.D. on Mar 17, 2020 3:00:00 AM

COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs.

Identifying these peptides have essential utilities:

  • Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity
  • Designing potent vaccines that elicit durable responses
T-cells are activated only by interacting with processed peptides (e.g. of SARS-CoV-2) that sit in the groove of MHC Class I and II molecules. Identifying these peptides can be used (in forms of peptide-MHC tetramers) to assess vaccine induced immunity and assist in designing potent vaccines with durable responses.
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Topics: Tetramer, Peptide, covid-19, SARS-CoV-2, vaccine, MHC

Quick!  Switch out your peptide! 

Posted by Marc Delcommenne, PhD on Mar 27, 2018 12:58:00 PM

The immunotherapy field is making great progress in aiding many disease treatments.  The hope is that one day, personalized immunotherapy can be used so each patient can use their own immune system to overcome their specific disease affliction.  QuickSwitch is a tool for creating custom MHC class I tetramers quickly and easily.

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Topics: Tetramer, QuickSwitch, Peptide, Peptide Exchange

Quick!  Switch out your peptide!

Posted by Marc Delcommenne, PhD on Jan 20, 2017 11:00:21 AM

The immunotherapy field is making great progress in aiding many disease treatments.  The hope is that one day, personalized immunotherapy can be used so each patient can use their own immune system to overcome their specific disease affliction.  QuickSwitch is a tool for creating custom MHC class I tetramers quickly and easily.

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Topics: Tetramer, QuickSwitch, Peptide, Peptide Exchange

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