Screening for COVID-19 T-cell peptides and immune monitoring with MHC tetramers in a single assay

Posted by Pirouz Daftarian, Ph.D., Marc Delcommenne, Ph.D. on Mar 17, 2020 3:00:00 AM

COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs.

Identifying these peptides have essential utilities:

  • Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity
  • Designing potent vaccines that elicit durable responses
T-cells are activated only by interacting with processed peptides (e.g. of SARS-CoV-2) that sit in the groove of MHC Class I and II molecules. Identifying these peptides can be used (in forms of peptide-MHC tetramers) to assess vaccine induced immunity and assist in designing potent vaccines with durable responses.
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Topics: Tetramer, Peptide, covid-19, SARS-CoV-2, vaccine, MHC

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