--- title: "S100 Proteins: Study their Hundreds of Functions with MBL ELISA Kits" description: S100 refers to proteins that are 100% soluble in saturated ammonium sulfate solution. image: https://blog.mblintl.com/hubfs/S100-family.png --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - S100 Proteins: Study their Hundreds of Functions with MBL ELISA Kits # S100 Proteins: Study their Hundreds of Functions with MBL ELISA Kits ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Tomohiro Nakajo](https://blog.mblintl.com/author/tomohiro-nakajo) on Jan 24, 2018 1:00:00 PM ![](https://blog.mblintl.com/hubfs/S100-family.png) Have you heard of the S100 protein family? S100 refers to proteins that are 100% soluble in saturated ammonium sulfate solution. They were first discovered as a major protein fraction (0.6% of total soluble proteins) isolated from bovine brain by B.W. Moore in 1965. The S100 protein family consists of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands), existing as a homodimer. Currently 20 family members are known and have been found to be secreted extracellularly as well as to be involved in intracellular signaling. Many of the functions of the S100 protein family are currently unknown. Recent research has suggested an association with various diseases such as cancer, inflammation, and atherosclerosis. For example, levels of S100A4, A6, A14, and P are upregulated in many cancers. S100A7 has been studied in skin inflammatory disease and S100A12 and Calprotectin (only one heterodimer consisting of S100A8 and A9) have been studied in inflammatory bowel disease.  ![S100-family.png](https://blog.mblintl.com/hubfs/S100-family.png) MBLI offers 12 sandwich ELISA kits for this protein family. If you want to know detailed information of each isoform of S100, please visit our [website](https://products.mblintl.com/?s=s100&post_type=product&title=1&excerpt=1&content=1&categories=1&attributes=1&tags=1&sku=1&orderby=rating-DESC&ixwps=1).  MBLI S100 ELISA kits are highly cited, particularly our S100A12 kit. Below is a partial list of citations with sample type and disease correlations. These kits have been used for the analysis of many diseases using various samples, not only serum/plasma but also cerebrospinal fluid (CSF), bronchoalveloar lavage fluid (BALF), and more. A citation highlight includes the measurement of S100A12 ([CY-8058V2](https://products.mblintl.com/products/cy-8058v2/)) in a stool sample. MBLI's S100A7 ELISA kit ([CY-8073](https://products.mblintl.com/products/cy-8073?__hstc=45788219.b78046e8a5bd2a2339e0d28794be725a.1708352385126.1708352385126.1708352385126.1&__hssc=45788219.1.1708352385126&__hsfp=1976201205)) can be used with the sample of washing fluid from skin. This sample preparation method is written in its [datasheet](https://products.mblintl.com/products/cy-8073/).  ![Table1a.jpg](https://blog.mblintl.com/hs-fs/hubfs/Table1a.jpg?width=618&height=337&name=Table1a.jpg) ![Table2a.jpg](https://blog.mblintl.com/hs-fs/hubfs/Table2a.jpg?width=618&height=377&name=Table2a.jpg) ![Table3a.jpg](https://blog.mblintl.com/hs-fs/hubfs/Table3a.jpg?width=618&height=252&name=Table3a.jpg) ![Table4c.jpg](https://blog.mblintl.com/hs-fs/hubfs/Table4c.jpg?width=644&name=Table4c.jpg) Lastly, I would like to introduce MBLI's new S100 ELISA kit, Calprotectin. As mentioned above, Calprotectin is a heterodimer of S100A8 and A9, and well known as a biomarker for Inflammatory Bowel Disease. Our RUO Calprotectin ELISA kit ([CY-8107](https://products.mblintl.com/products/cy-8107)) can measure the S100A8 and A9 heterodimer, without cross reactivity with each homodimer. We employ capture antibody recognizing both S100A8 homodimer and Calprotectin and a detection antibody recognizing only Calprotectin. MBLI's S100A8 ([CY-8061](https://products.mblintl.com/products/cy-8061)) and S100A9 ([CY-8062](https://products.mblintl.com/products/cy-8062)) ELISA kits do not cross-react with Calprotectin. Given their relevance to a variety of diseases, S100 likely plays a role in your research pathway of interest. Please visit our [website](https://mblintl.com/) to learn more! Tags: [ELISA](https://blog.mblintl.com/topic/elisa), [S100 Proteins](https://blog.mblintl.com/topic/s100-proteins) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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