--- title: Why Smart-IP is the smart way to IP description: The right IP antibody can make your life easier. Smart-IP antibodies give you high recovery and it's a fast procedure. You'll enjoy running IP assays. Find out how easy it is! image: https://blog.mblintl.com/hubfs/smart_ip.jpg --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - Why Smart-IP is the smart way to IP # Why Smart-IP is the smart way to IP ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Bindi M. Doshi, PhD](https://blog.mblintl.com/author/bindi-m-doshi-phd) on May 28, 2015 10:49:05 AM ![](https://blog.mblintl.com/hubfs/smart_ip.jpg) You have been given the mission to start a new project. A tiny tube is put in your hands and you’re told it contains a potentially interesting protein and your job is to characterize it. After you wipe nervous sweat from your brow, you get down to business. Step one- how to isolate your new buddy? Immunoprecipitation can help with this question! You determine which epitope tag is on your protein and go to [mblintl.com](https://mblintl.com/) to see what you can buy to help this new adventure. You see there are antibodies conjugated to magnetic beads, which help protein pull downs from cell lysates. It's easy, it's fast.  Hmmmm- promising. Smart IP magnetic beads and its corresponding tag antibody are covalently conjugated. The magnetic beads are 1.5 µm in diameter in size. The amount of antibody/bead is listed below: | **Code No.** | **Immunogen** | **IgG Volume** | **Beads volume** | **Number of Beads** | **Antibody/Beads (pg/beads)** | | --- | --- | --- | --- | --- | --- | | [D153-11](https://products.mblintl.com/products/d153-11) | GFP | 160 ug | 10 mg | 4x10^9 | 0.04 | | [D291-11](https://products.mblintl.com/products/d291-11) | His | 130 ug | 10 mg | 4x10^9 | 0.0325 | | [M047-11](https://products.mblintl.com/products/m047-11) | Myc | 300 ug | 15 mg | 6x10^9 | 0.05 | | [M132-11](https://products.mblintl.com/products/m132-11) | HA | 210 ug | 10 mg | 4x10^9 | 0.0525 | | [M167-11](https://products.mblintl.com/products/m167-11) | V5 | 180 ug | 10 mg | 4x10^9 | 0.045 | | [M165-11](https://products.mblintl.com/products/m165-11) | RFP | 140 ug | 10 mg | 4x10^9 | 0.035 | | [M185-11](https://products.mblintl.com/products/m185-11) | DDDDK | 360 ug | 15 mg | 6x10^9 | 0.06 | | [M180-11](https://products.mblintl.com/products/m180-11) | HA | 250 ug | 10 mg | 4x10^9 | 0.0625 | | [M075-11](https://products.mblintl.com/products/m075-11) |   | 83 ug | 10 mg | 4x10^9 | 0.0208 | | [M076-11](https://products.mblintl.com/products/m076-11) |   | 150 ug | 10 mg | 4x10^9 | 0.0375 | | [M077-11](https://products.mblintl.com/products/m077-11) |   | 150 ug | 10 mg | 4x10^9 | 0.0375 | | [M081-11](https://products.mblintl.com/products/m081-11) |   | 210 ug | 10 mg | 4x10^9 | 0.0525 | 10 mg beads = 4 x 10^9 beads In addition, the Smart IP series do not require a pre-clear step. Some labs choose to pre-clear to reduce non-specific binding. To do this, it is best to use an irrelevant antibody.  While MBL does not believe a pre-clear step is necessary, if you believe your sample contains some non-specific binding issues, we recommend [M081-11](https://products.mblintl.com/products/m081-11) (isotype control beads) for a pre-clear step. Now you have information. You can plan your experiment, characterize your protein, and make your PI happy.   Watch our super cool Smart-IP video! [http://youtu.be/\_4kR3Wxlbpk](http://youtu.be/_4kR3Wxlbpk)     [![Contact Us!](https://no-cache.hubspot.com/cta/default/424171/6abbd33e-e1c2-4474-bc75-5f4529bb948a.png)](https://cta-redirect.hubspot.com/cta/redirect/424171/6abbd33e-e1c2-4474-bc75-5f4529bb948a)         Tags: [Epitope Tag](https://blog.mblintl.com/topic/epitope-tag) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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