--- title: Who’s that on my mRNA? description: Find out more about RBP and mRNA binding using RiboTrap! image: https://blog.mblintl.com/hubfs/RiboTrap-Principle2013-2-01-250x300.jpg --- **Please Note:** MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: [https://www.cosmobiousa.com/](https://www.cosmobiousa.com/). For Non-US inquiries reach out to MBL in Japan: [https://www.mblbio.com/](https://www.mblbio.com/). 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[Home](https://blog.mblintl.com/) - [Blogs](https://blog.mblintl.com) - Who’s that on my mRNA? # Who’s that on my mRNA? ### Topics - Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine ### Top Posts ### Subscribe to our Blogs Published by [Bindi M. Doshi, PhD](https://blog.mblintl.com/author/bindi-m-doshi-phd) on May 17, 2016 2:44:01 PM ![](https://blog.mblintl.com/hubfs/RiboTrap-Principle2013-2-01-250x300.jpg) You have an RNA of interest aka your favorite RNA. The question is: which RBPs interact with it? Who are these RBPs and what are their intentions with your precious RNA? It’s not yet known how diseases are regulated or at which point protein transcription/translation are altered to cause disease. Studies have found that there are specific RNA Binding Proteins (RBPs) for their respective mRNA. The nature of this interaction is dynamic. For example, regulatory signals influence binding of RBP and RNA, one RNA can have more than one RBP, and one RBP can bind with different RNAs.[1](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858862/) Researchers are working hard to develop a greater knowledge base for how these diverse proteins interact with many different RNAs. In order to better understand the dynamic nature of this transcriptional regulation, RNP (ribonucleoprotein) complexes are being investigated. As you know, it is important to carry this investigation on with a system that involves the least amount of outside influence. After all, you want to capture the "true" relationship of RBPs and their mRNAs. One method for investigating the RBP and RNA interaction is to do an RNA pull down assay. IP’s are great for investigating interactions. MBL’s [RiboTrap](https://products.mblintl.com/products/rn1011-rn1012) kit comes with an anti-BrdU antibody and various buffers. This antibody will isolate the labeled mRNA of interest and pull down the mRNA and any proteins binding with it, in (or under) native conditions. MBL’s kit utilizes three different wash buffers so you can analyze weakly bound proteins or very tightly bound proteins. There is the option of using a basic buffer, high salt buffer, or strong detergent buffer. Be cautious though! Just because you find the strongest interaction using any or all of the three buffers, it doesn’t necessarily mean this is the function RBP/RNA interaction. It’s just the strongest. Be sure to plan more fun experiments to characterize the functionality of any newly discovered binding. Once you run your proteins out on SDS-PAGE gel, excise the bands, and analyze using LC-MS/MS. You now have a better picture of interactions between your favorite mRNA and what RBPs bind to it.  Now to figure out the intentions.... Useful Publications: [http](http://www.ncbi.nlm.nih.gov/pubmed/1836997)://www.ncbi.nlm.nih.gov/pubmed/1836997 ![RiboTrap-Principle2013-2-01-250x300.jpg](https://blog.mblintl.com/hubfs/RiboTrap-Principle2013-2-01-250x300.jpg "RiboTrap-Principle2013-2-01-250x300.jpg") 1.  Glisovic, Tina, Jennifer L. Bachorik, Jeongsik Yong, and Gideon Dreyfuss. "RNA-binding Proteins and Post-transcriptional Gene Regulation." *FEBS Letters* 582.14 (2008): 1977-986.                   Tags: [RNA](https://blog.mblintl.com/topic/rna), [Epigenetics](https://blog.mblintl.com/topic/epigenetics), [Gene Regulation](https://blog.mblintl.com/topic/gene-regulation), [RiboTrap](https://blog.mblintl.com/topic/ribotrap), [RBP](https://blog.mblintl.com/topic/rbp) --- [Back to Blog](https://blog.mblintl.com) --- ### Comments Or Suggestions ## Related Articles ### Sign up for our latest news and promotions. 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