SARS-CoV-2 is the virus that causes the COVID-19 disease (Coronovirus Disease 2019). MBLI understands the urgent need to have better understanding and characterization of this disease in order to find treatments and vaccines. We are continuing to develop and launch new products for the research community as fast as we can.
T-cells are activated only by interacting with processed peptides (e.g. of SARS-CoV-2) that sit in the groove of MHC Class I and II molecules. Identifying these peptides can be used (in forms of peptide-MHC tetramers) to asses vaccine induced immunity and to assist in designing potent vaccines with durable responses. COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs. Identifying these peptides has essential utilities:
- Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity
- Designing potent vaccines that elicit durable responses
MBL International can assist companies and academic investigators who are actively developing coronavirus vaccines with our unique QuickSwitch™ custom tetramer platform. QuickSwitch™ is a peptide screening plug and play platform that identifies peptides that are more likely to be immunogenic and yet generates corresponding Class I and Class II MHC tetramers. This platform can identify and validate multi-epitope candidates of SARS-CoV-2 proteins that can potentially elicit for both CD4+ and CD8+ T-cell immune responses. By using MBLI’s MHC tetramer exchange QuickSwitch™ platform for peptide screening, you can identify/validate the binding of predicted peptide sequences of the COVID-19 viral proteins in most common alleles: HLA-A2, A11, A24, A3 and HLA-DR1, DR4, DR15.
We are excited to offer QuickSwitch kit and peptide bundles specifically for SARS-CoV-2 research. Discover more about the kits and peptide sequences in each bundle by clicking the button below:
QuickSwitch™ kit & peptides bundle
Product Highlights
MHC Tetramers for COVID-19 Cell Detection
| Product Code | Class | Sequence | Target |
|---|---|---|---|
| TB-0174-1 | Class I | RLNEVAKNL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0174-2 | Class I | RLNEVAKNL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0174-4 | Class I | RLNEVAKNL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0174-M | Class I | RLNEVAKNL | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0174-M2 | Class I | RLNEVAKNL | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0175-1 | Class I | KLPDDFTGCV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0175-2 | Class I | KLPDDFTGCV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0175-4 | Class I | KLPDDFTGCV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0175-M | Class I | KLPDDFTGCV | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0175-M2 | Class I | KLPDDFTGCV | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0176-1 | Class I | YLQPRTFLL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0176-2 | Class I | YLQPRTFLL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0176-4 | Class I | YLQPRTFLL | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer |
| TB-0176-M | Class I | YLQPRTFLL | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0176-M2 | Class I | YLQPRTFLL | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0177-1 | Class I | RLQSLQTYV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer- |
| TB-0177-2 | Class I | RLQSLQTYV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer- |
| TB-0177-4 | Class I | RLQSLQTYV | HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer- |
| TB-0177-M | Class I | RLQSLQTYV | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
| TB-0177-M2 | Class I | RLQSLQTYV | Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer |
Peptides for COVID-19 Cell Detection
| SPC001 | SARS-CoV-2 ORF1ab polyprotein (3906-3920) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | EAFEKMVSLLSVLLS |
| SPC002 | SARS-CoV-2 ORF1ab polyprotein (471-485) Peptide | HLA-DRB1*01:01, HLA-DRB1*15:01 | EEIAIILASFSASTS |
| SPC003 | SARS-CoV-2 ORF1ab polyprotein (1801-1815) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | ESPFVMMSAPPAQYE |
| SPC004 | SARS-CoV-2 envelope protein (56-70) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | FYVYSRVKNLNSSRV |
| SPC005 | SARS-CoV-2 ORF1ab polyprotein (2211-2225) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | LEASFNYLKSPNFSK |
| SPC006 | SARS-CoV-2 nucleocapsid phosphoprotein (221-235) Peptide | HLA-DRB1*01:01 | LLLLDRLNQLESKMS |
| SPC007 | SARS-CoV-2 membrane glycoprotein (176-190) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | LSYYKLGASQRVAGD |
| SPC008 | SARS-CoV-2 ORF3a protein (1-15) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | MDLFMRIFTIGTVTL |
| SPC009 | SARS-CoV-2 membrane glycoprotein (91-105) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | MWLSYFIASFRLFAR |
| SPC010 | SARS-CoV-2 ORF1ab polyprotein (5016-5030) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | RAMPNMLRIMASLVL |
| SPC011 | SARS-CoV-2 ORF1ab polyprotein (3946-3960) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | SEFSSLPSYAAFATA |
| SPC012 | SARS-CoV-2 chain A spike glycoprotein (236-250) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | TRFQTLLALHRSYLT |
| SPC013 | SARS-CoV-2 nucleocapsid phosphoprotein (301-315) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | WPQIAQFAPSASAFF |
| SPC014 | SARS-CoV-2 ORF3a protein (206-220) Peptide | HLA-DRB1*01:01, HLA-DRB1*04:01 | YFTSDYYQLYSTQLS |
| SPC015 | SARS-CoV-2 ORF1ab (3122-3130) Peptide | HLA-A*02:01 | FLAHIQWMV |
| SPC016 | SARS-CoV-2 ORF1ab (3183-3191) Peptide | HLA-A*02:01 | FLLNKEMYL |
| SPC017 | SARS-CoV-2 ORF1ab (6749-6758) Peptide | HLA-A*02:01 | LLLDDFVEII |
| SPC018 | SARS-CoV-2 ORF3a protein (139-147) Peptide | HLA-A*02:01 | LLYDANYFL |
| SPC019 | SARS-CoV-2 ORF1ab (3732-3740) Peptide | HLA-A*02:01 | SMWALIISV |
| SPC020 | SARS-CoV-2 ORF1ab (3710-3718) Peptide | HLA-A*02:01 | TLMNVLTLV |
| SPC021 | SARS-CoV-2 ORF1ab (6419-6427) Peptide | HLA-A*02:01 | YLDAYNMMI |
| SPC022 | SARS-CoV-2 ORF1ab (6851-6859) Peptide | HLA-A*02:01 | YLNTLTLAV |
| SPC023 | SARS-CoV-2 ORF3a protein (107-115) Peptide | HLA-A*02:01 | YLYALVYFL |
| SPC024 | SARS-CoV-2 ORF1ab (2192-2200) Peptide | HLA-A*03:01, HLA-A*11:01 | ASMPTTIAK |
| SPC025 | SARS-CoV-2 ORF1ab (4892-4900) Peptide | HLA-A*03:01, HLA-A*11:01 | KSAGFPFNK |
| SPC026 | SARS-CoV-2 nucleocapsid phosphoprotein (362-370) Peptide | HLA-A*03:01, HLA-A*11:01 | KTFPPTEPK |
| SPC027 | SARS-CoV-2 ORF1ab (2600-2608) Peptide | HLA-A*03:01, HLA-A*11:01 | STFNVPMEK |
| SPC028 | SARS-CoV-2 ORF1ab (1875-1883) Peptide | HLA-A*03:01, HLA-A*11:01 | TTIKPVTYK |
| SPC029 | SARS-CoV-2 ORF1ab (6159-6167) Peptide | HLA-A*24:02 | DYVYNPFMI |
| SPC030 | SARS-CoV-2 ORF1ab (4986-4994) Peptide | HLA-A*24:02 | FYGGWHNML |
| SPC031 | SARS-CoV-2 ORF1ab (3159-3167) Peptide | HLA-A*24:02 | NYLKRRVVF |
| SPC032 | Chain A, SARS-CoV-2 spike glycoprotein (539-546) Peptide | H-2 Kb | VNFNFNGL |
| SPC033 | Chain A, SARS-CoV-2 spike glycoprotein (902-909) Peptide | H-2 Kb | MAYRFNGI |
| SPC034 | Chain A, SARS-CoV-2 spike glycoprotein (233-241) Peptide | H-2 Kb | INITRFQTL |
| SPC035 | Chain A, SARS-CoV-2 spike glycoprotein (511-518) Peptide | H-2 Kb | VVLSFELL |
| SPC036 | Chain A, SARS-CoV-2 spike glycoprotein (325-332) Peptide | H-2 Kb | SIVRFPNI |
| SPC037 | Chain A, SARS-CoV-2 spike glycoprotein (447-455) Peptide | H-2 Kb | GNYNYLYRL |
| SPC038 | Chain A, SARS-CoV-2 spike glycoprotein (1060-1068) Peptide | HLA-A*02:01, H-2 Kb | VVFLHVTYV |
| SPC039 | Chain A, SARS-CoV-2 spike glycoprotein (691-699) Peptide | HLA-A*02:01, H-2 Kb | SIIAYTMSL |
| SPC040 | Chain A, SARS-CoV-2 spike glycoprotein (424-433) Peptide | HLA-A*02:01 | KLPDDFTGCV |
| SPC041 | ORF1ab polyprotein SARS-CoV-2 (5385-5393) Peptide | H-2 Kb | VTQLYLGGM |
| SPC042 | ORF1ab polyprotein SARS-CoV-2 (5583-5591) Peptide | HLA-A*02:01 | ISDEFSSNV |
| SPC043 | ORF1ab polyprotein SARS-CoV-2 (5573-5580) | H-2 Kb | ITGLYPTL |
| SPC044 | Chain A, SARS-CoV-2 spike glycoprotein (263-270) | H-2 Kb | AAYYVGYL |
| SPC045 | Chain A, SARS-CoV-2 spike glycoprotein (449-456) | H-2 Kb | YNYLYRLF |
| SPC046 | SARS-CoV-2 chain A spike glycoprotein (363-377) | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | ADYSVLYNSASFSTF |
| SPC047 | SARS-CoV-2 surface glycoprotein (1216-1230) | HLA-DRB1*01:01, HLA-DRB1*04:01 | IWLGFIAGLIAIVMV |
| SPC048 | SARS-CoV-2 envelope protein (21-35) | HLA-DRB1*01:01 | LAFVVFLLVTLAILT |
| SPC049 | SARS-CoV-2 ORF7a protein (1-15) | HLA-DRB1*01:01, HLA-DRB1*04:01 | MKIILFLALITLATC |
| SPC050 | SARS-CoV-2 membrane glycoprotein (41-55) | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | NRNRFLYIIKLIFLW |
| SPC051 | SARS-CoV-2 chain A spike glycoprotein (509-523) | HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 | RVVVLSFELLHAPAT |
| SPC052 | SARS-CoV-2 chain A spike glycoprotein (51-65) | HLA-DRB1*04:01, HLA-DRB1*15:21 | TQDLFLPFFSNVTWF |
| SPC053 | SARS-CoV-2 Spike Glycoprotein Peptide-RLNEVAKNL | HLA-A*02:01 | RLNEVAKNL |
| SPC054 | SARS-CoV-2 Spike Glycoprotein Peptide-YLQPRTFLL | HLA-A*02:01 | YLQPRTFLL |
| SPC055 | SARS-CoV-2 Spike Glycoprotein Peptide-RLQSLQTYV | HLA-A*02:01 | RLQSLQTYV |
| SPC056 | Chain A, SARS-CoV-2 spike glycoprotein (495-503) wild type | HLA-A*02:01 | YGFQPTNGV |
| SPC057 | Chain A, SARS-CoV-2 spike glycoprotein (495-503) N501Y mutant | HLA-A*02:01 | YGFQPTYGV |
| SPC058 | Chain A, SARS-CoV-2 spike glycoprotein (484-492) wild type | HLA-A*02:01 | EGFNCYFPL |
| SPC059 | Chain A, SARS-CoV-2 spike glycoprotein (484-492) E484K mutant | HLA-A*02:01 | KGFNCYFPL |
| SPC060 | Chain A, SARS-CoV-2 spike glycoprotein (493-501) N501Y mutant | HLA-A*03:01 | QSYGFQPTY |
| SPC062 | SARS-CoV-2 ORF1ab polyprotein (1326-1334) | HLA-A*01:01 | PTDNYITTY |
| SPC063 | SARS-CoV-2 ORF1ab polyprotein (1642-1650) | HLA-A*01:01 | TTDPSFLGR |
| SPC064 | SARS-CoV-2 chain A spike glycoprotein (255-263) | HLA-A*01:01 | WTAGAAAYY |
| SPC065 | SARS-CoV-2 chain A spike glycoprotein (958-966) | HLA-A*02:01 | ALNTLVKQL |
| SPC066 | SARS-CoV-2 ORF3a protein (75-83) | HLA-A*02:01 | ALSKGVHFV |
| SPC067 | SARS-CoV-2 ORF1ab polyprotein (4099-4107) | HLA-A*02:01 | ALWEIQQVV |
| SPC068 | SARS-CoV-2 chain A spike glycoprotein (1220-1228) | HLA-A*02:01 | FIAGLIAIV |
| SPC069 | SARS-CoV-2 nucleocapsid phosphoprotein (316-324) | HLA-A*02:01 | GMSRIGMEV |
| SPC070 | SARS-CoV-2 nucleocapsid phosphoprotein (351-359) | HLA-A*02:01 | ILLNKHIDA |
| SPC071 | SARS-CoV-2 ORF1ab polyprotein (3891-3899) | HLA-A*02:01 | KLWAQCVQL |
| SPC072 | SARS-CoV-2 nucleocapsid phosphoprotein (222-230) | HLA-A*02:01 | LLLDRLNQL |
| SPC073 | SARS-CoV-2 chain A spike glycoprotein (1192-1200) | HLA-A*02:01 | NLNESLIDL |
| SPC074 | SARS-CoV-2 membrane glycoprotein (61-70) | HLA-A*02:01 | TLACFVLAAV |
| SPC075 | SARS-CoV-2 chain A spike glycoprotein (958-966) | HLA-A*02:01 | VLNDILSRL |
| SPC076 | SARS-CoV-2 membrane glycoprotein (171-180) | HLA-A*03:01, HLA-A*11:01 | ATSRTLSYYK |
| SPC077 | SARS-CoV-2 chain A spike glycoprotein (378-386) | HLA-A*03:01, HLA-A*11:01 | KCYGVSPTK |
| SPC078 | SARS-CoV-2 ORF1ab polyprotein (4678-4686) | HLA-A*03:01, HLA-A*11:01 | KLFDRYFKY |
| SPC079 | SARS-CoV-2 ORF1ab polyprotein (282-290) | HLA-A*03:01, HLA-A*11:01 | KTIQPRVEK |
| SPC081 | SARS-CoV-2 chain A spike glycoprotein (454-462) | HLA-A*03:01, HLA-A*11:01 | RLFRKSNLK |
| SPC082 | SARS-CoV-2 ORF1ab polyprotein (4221-4229) | HLA-A*03:01, HLA-A*11:01 | VTDTPKGPK |
| SPC083 | SARS-CoV-2 ORF1ab polyprotein (5538-5547) | HLA-A*03:01, HLA-A*11:01 | VVYRGTTTYK |
| SPC084 | SARS-CoV-2 nucleocapsid phosphoprotein (134-143) | HLA-A*11:01 | ATEGALNTPK |
| SPC085 | SARS-CoV-2 ORF1ab polyprotein (282-290) | HLA-A*24:02 | FYAYLRKHF |
| SPC086 | SARS-CoV-2 chain A spike glycoprotein (454-462) | HLA-A*24:02 | QYIKWPWYI |
| SPC087 | SARS-CoV-2 chain A spike glycoprotein (78-86) | HLA-A*24:02 | RFDNPVLPF |
| SPC088 | SARS-CoV-2 ORF3a protein (114-122) | HLA-A*24:02 | VYFLQSINF |
| SPC089 | SARS-CoV-2 ORF1ab polyprotein (5726-5734) | HLA-A*24:02 | VYIGDPAQL |
| SPC090 | SARS-CoV-2 ORF1ab polyprotein (1541-1549) | HLA-A*24:02 | YYTSNPTTF |
| SPC091 | SARS-CoV-2 ORF1ab polyprotein (2954-2962) | HLA-B*07:02 | RPDTRYVLM |
| SPC092 | SARS-CoV-2 ORF1ab polyprotein (5921-5929) | HLA-B*07:02 | IPRRNVATL |
| SPC093 | SARS-CoV-2 ORF1ab polyprotein (2954-2961) | HLA-B*07:02 | RPDTRYVL |
| SPC094 | SARS-CoV-2 chain A spike glycoprotein (1056-1063) | HLA-B*07:02 | APHGVVFL |
| SPC095 | SARS-CoV-2 ORF1ab polyprotein (4168-4176) | HLA-A*01:01 | CTDDNALAY |
| SPC096 | SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (367-376) (S371D, S373P, S375F) | HLA-A*02:01 | VLYNLAPFFT |
| SPC097 | SARS-CoV-2 Spike Glycoprotein Peptide WT (367-376) | HLA-A*02:01 | VLYNSASFST |
| SPC098 | SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (367-378) (S371D, S373P, S375F) | HLA-A*03:01 | VLYNLAPFFTFK |
| SPC099 | SARS-CoV-2 Spike Glycoprotein Peptide WT (367-378) | HLA-A*03:01 | VLYNSASFSTFK |
| SPC100 | SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (366-378) (S371D, S373P, S375F) | HLA-A*11:01 | SVLYNLAPFFTFK |
| SPC101 | SARS-CoV-2 Spike Glycoprotein Peptide WT (366-378) | HLA-A*11:01 | SVLYNSASFSTFK |
| SPC102 | SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (368-377) (S371D, S373P, S375F) | HLA-A*24:02 | LYNLAPFFTF |
| SPC103 | SARS-CoV-2 Spike Glycoprotein Peptide WT (368-377) | HLA-A*24:02 | LYNSASFSTF |
Learn more about COVID-19 by reading our blog post
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