---
title: How to detect functional PCSK9 quickly and easily 
description: Detect functional PCSK9 in your serum or plasma sample quickly and easily with our new ELISA kit!
image: https://blog.mblintl.com/hubfs/CholesterolPathway.jpg
---

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- How to detect functional PCSK9 quickly and easily 

# How to detect functional PCSK9 quickly and easily 

### Topics

- Select Topic - 3D Cell Culture Advancements in Metabolism Research Allergy Antibodies Antibody Antibody Reagents Antibody-Peptide Conjugates Apoptosis Assay and Kits Autoimmune Disease Autophagy BRIC Benefits of Tetramer Assays Biomarker Cancer Cell Biology Cell Culture Reagents Cell Stabilization Custom Peptide Synthesis Cytokine Dextramer Staining Drug Discovery ELISA Epigenetics Epitope Tag Exosome Exosomes FCM Fc blocker Flow Cytometry Flow Cytometry Antibodies Fluoppi Fluorescent Proteins Future of Tetramer Technology Gastric Inhibitory Peptide Gene Regulation Gene Therapy Green Fluorescent Protein IL-18 Immune Response Immunology Inflammation Isotype Control Kits and Assays LC3 Liquid Biopsy MHC MHC Alleles MHC Class II Tetramers MHC Peptides Contribute MHC Tetramer MHC Tetramer Protocol MHC tetramer advancements Metabolism Mitophagy NCP Neuroscience Neuroscience Reagents Organoid PCSK9 PCSK9 ELISA Kit Peptide Peptide Exchange Peptide Synthesis Methods Peptide Synthesis Service Peptide-Infused Skin Care Products Preservation Purify exosome Quality Control QuickSwitch Quickswitch™ Custom Tetramer Kits RBP RIP Chip RNA Recombinant Protein Production Recombinant Proteins Regulation RiboTrap S100 Proteins SARS-CoV-2 T-Cell Detection TCR Tetramers Tetramer Tetramer Analysis Tetramer Assay Tetramer Assay Protocol Tetramer Staining TransFix Vectors Western Reagents atg8 covid-19 gfp keima red kinases mitochondria cell death p62 pathways phosphorylation pro IL-18 reagents rfp t cell tuberculosis ultracentrifugation vaccine

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Published by [Bindi M. Doshi, PhD](https://blog.mblintl.com/author/bindi-m-doshi-phd) on Mar 30, 2018 2:45:00 PM

![](https://blog.mblintl.com/hubfs/CholesterolPathway.jpg)

PCSK9 remains an important target in cholesterol research.  One of the hurdles in this research area is determining which PSCK9 form is present and binding with LDLR.  Our new Human PCSK9 Functional Assay Kit is designed to detect active PSCK9 binding with LDLR. 

Briefly, PCSK9 binds to LDLR (which is located on the membrane) and marks it for recycling, thereby resulting in fewer LDLR receptors available to collect and internalize circulating LDL. This can lead to hypercholesterolemia in some individuals.  It has been observed that when PCSK9 is inhibited, plasma LDL-cholesterol is also lowered.  For this reason, doctors and pharmaceutical companies are interested in this metabolism target. We have a couple [previous blog posts](https://blog.mblintl.com/topic/metabolism) to refresh your memory. 

When PCSK9 is synthesized, it is inactive.   Proprotein convertases remove the activity blocking peptide chain, resulting in PCSK9 activation.  PCSK9 can be present in different forms- active, non-active, or a mutated state. So how do you know if PCSK9 is actually binding to LDLR?  Which form is binding?  Can you add an inhibitor and be able to measure this binding? Our new [PCSK9 functional assay ELISA](https://products.mblintl.com/products/cy-8153) kit will help you! This kit is primarily designed for the semi-quantitative in vitro measurement of functionally active PCSK9 in serum and plasma, which is capable of binding to LDL receptor (LDLR).  The assay system of #CY-8153 detects the binding between LDLR and active PCSK9. Recombinant LDLR is immobilized in the wells, and allows for the binding of functional PCSK9.  Anti-PSCK9 antibodies are then used to detect binding.

We offer various PCSK9 kits.  Discover your perfect kit below:

|   | [CY-8153](https://products.mblintl.com/products/cy-8153) | [CY-8079](https://products.mblintl.com/products/cy-8079) | [CY-8150](https://products.mblintl.com/products/cy-8150) |
| --- | --- | --- | --- |
| Product Name | Human PCSK9 Functional Assay Kit | Human PCSK9 ELISA Kit | PCSK9-LDLDR *in vitro* Binding Assay Kit |
| Use | Detect active PCSK9 | Detect Active and Non-Active PCSK9 | Screen inhibitors of PCSK9 and LDLR |
| Sample Type | Serum and Plasma | Serum and Plasma |  *In vitro* |

 

Tags: [PCSK9](https://blog.mblintl.com/topic/pcsk9), [Metabolism](https://blog.mblintl.com/topic/metabolism), [PCSK9 ELISA Kit](https://blog.mblintl.com/topic/pcsk9-elisa-kit)

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