The Lab Notebook

Investigating Parkinson's Disease Part III: The Role of PARK7/DJ-1

Posted by Bindi M. Doshi, PhD on Mar 17, 2015 7:00:00 AM
In the biomedical field, DJ-1 is a target of interest in a variety of disease states.  DJ-1 is considered a contender for a biomarker in the detection of early stage cerebral infraction since it’s concentration increases 3 hours after cerebral injury. When DJ-1 is expressed in excess, it can lead to cancer. For instance, breast cancer patients show increased levels of circulating DJ-1 and anti-DJ-1 antibodies. 3  However, a loss of function can lead to neuodegenerative diseases such autosomal early-onset Parkinson’s disease. 2  
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Topics: Neuroscience

Investigating Parkinson's Disease Part II: The Role of PARK5/UCHL1

Posted by Bindi M. Doshi, PhD on Mar 16, 2015 5:03:04 PM
PARK genes are associated with Parkinson's Disease. The cause of Parkinson's Disease is not currently known and the progression of the disease (on a molecular level) is not well established.  Human UCHL1 ELISA Kit  and Mouse UCHL1 ELISA Kit  has the ability to specifically detect UCHL1.
 
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Topics: Neuroscience

Investigating Parkinson's Disease Part I: Mitophagy & How to Visualize It

Posted by Glen Molotnikov on Mar 13, 2015 2:47:48 PM

Mitophagy is the selective degradation of old or depolarized mitochondria by autophagy, mitophogy contributes to maintaining a healthy population of mitochondria. Since damaged mitochondria leads to collapsed cell homeostasis, mitophagy is believed to protect against diseases related to mitochondrial dysfunction such as neurodegenerative disorders, most importantly Parkinson's Disease.

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Topics: Fluorescent Proteins, Neuroscience