The Lab Notebook

The Significance of IL-18 in the Inflammatory Response

Posted by Deane Buckley on Mar 9, 2015 10:30:48 AM

Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.

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Topics: Immunology, IL-18, Immune Response, Allergy

Why bother knowing if you are detecting Pro-IL18 or active IL-18?

Posted by Bindi M. Doshi, PhD on Mar 2, 2015 9:48:00 AM

il-18-01Antibodies are wonderful.  They can act as little detectives to help you determine if the protein you’re interested in is involved in a certain process or help characterize the function.  But what if your favorite protein has two forms?  Is your antibody sophisticated enough to be able to detect one form over the other?  Does this knowledge help you?  How?  IL-18 is one such protein that has two forms.  It is present when it is inactive and present when it is active.  So what is known about IL-18 and its function and the two forms it can exist in?

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Topics: Immunology, IL-18, Immune Response, Allergy