The Lab Notebook

Give Your Research 100% With a S100 Antibody

Posted by Deane Buckley on Jul 7, 2015 10:00:00 AM
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Image of S100 Role in MAP KInase and NF Kappa Beta Pathways

Figure: Schematic representation of S100 proteins in the MAP kinase and NF-kappaB pathways.

S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.

  1. The S100 protein family consists of 21 proteins that exhibit structural similarity. However, many of the proteins differ in their function1.
  2. Calcium binding activates S100 proteins. S100 proteins undergo a conformation change, thereby allowing interaction with other proteins2.
  3. S100 proteins regulate levels of nucleic acids and a variety of proteins such as enzymes, receptors and transcription factors3.
  4. Some S100 proteins interact with intracellular targets. An example is S100A6, which can bind p53 in the cytosol to regulate apoptosis3.
  5. Some S100 proteins interact with extracellular targets. These interactions include binding to extracellular receptors or binding extracellular circulating proteins3.
  6. S100 proteins are involved in many important cellular processes such as apoptosis, inflammation, energy metabolism and proliferation3.
  7. S100 proteins have been implicated in a variety of cancers1,2. The specific ways S100 proteins are involved in cancer will be discussed in a future post.

 

Parkinson's Disease Poster Including DJ1 (PARK7)



MBL International offers a variety of S100 products to meet your research needs including S100 antibodies and S100 ELISA Kits. With a S100 antibody and a S100 ELISA kit, it'll be easier for you to further explore these fascinating proteins.

Citations:

1. Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer. Nat Rev Cancer. 2015;15(2):96-109.

2. Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4(2):89-115.

3. Donato R, Cannon BR, Sorci G, et al. Functions of S100 proteins. Curr Mol Med. 2013;13(1):24-57.

Topics: Immunology, Apoptosis, Cancer