Figure: Schematic representation of feedback loop involving CLOCK-BMAL1 complex and CRY and PER proteins involved in creating circadian rhythms.
Tiredness and frustration often mount after long nights in the lab. Why can’t our bodies adjust and allow us to maintain our energy through the night? The answer lies in our circadian rhythms. Circadian rhythms are the daily cycle of biological processes such as wakefulness and metabolism1. Many proteins are involved in regulating our circadian rhythms including CRY proteins. This blog post will catch you up on these proteins and their vital role in regulating circadian rhythms.
MBL International offers a CRY1 antibody, a CRY2 antibody and other products to further your research. With these CRY antibodies there will be no more crying in the lab over frustration with your circadian rhythm research!
4. Kondratov RV, Chernov MV, Kondratova AA, Gorbacheva VY, Gudkov AV, Antoch MP. BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 2003;17(15):1921-32.