PARK genes are associated with Parkinson's Disease. The cause of Parkinson's Disease is not currently known and the progression of the disease (on a molecular level) is not well established. Human UCHL1 ELISA Kit and Mouse UCHL1 ELISA Kit has the ability to specifically detect UCHL1.
Ubiquitin Carboxy-terminal Hydrolase L1 (UCHL1) (also PARK5) is a carboxyl-terminal ubiquitin hydrolase regulating ubiquitin dependent signaling pathways. It's exact role is not fully understood. Using UCHL1's hydrolase activity, ubiquitin molecules are removed and recycled from degraded proteins. It has ligase function, where ubiquitin molecules are added for tagging proteins for degradation. It is expressed predominantly in neurons, as well as in testis and ovaries. Mutations in this target were found to be responsible for a genetic form of Parkinson’s Disease.1 It is thought a mutation at amino acid position 93 for methionine may decrease UCHL1 hydrolase activity, leading to accumulation of proteins that should have been degraded, and subsequently the progression of Parkinson's disease.
To further help you investigate the molecular progression of Parkinson's Disease, MBL International offers a UCHL1 quantitative detection kit for human samples and a separate kit for mouse samples. Cell lysate, cell culture supernatant, and other biological media can be used with the kit.
- Contu, V., Kotake, Y., Toyama, T., Okuda, K., Miyara, M., Sakamoto, S., ... Ohta, S. (2014). Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. Journal of Neurochemistry, 130(6), 826-38.